jvla@joannavargas.com
(310) 424-5141 (call or text)
salon@joannavargas.com
(212) 949-2350 (call or text)
By Emily Wyatt · Published December 4, 2023 · Updated February 10, 2025
Seeing sun spots, acne scarring, or rough texture that just won't go away? Even out your pigment and reduce inflammation and redness in just three months with our BRIGHTEN AND GLOW spa bundle series.

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jvla@joannavargas.com
(310) 424-5141 (call or text)
salon@joannavargas.com
(212) 949-2350 (call or text)

Yes, XERF may be incorporated into a treatment plan with Botox or other neuromodulators, dermal fillers, biostimulatory injectables, lasers and selected ultrasound procedures. XERF uses noninvasive radiofrequency energy to heat tissue and support skin tightening, while neuromodulators address expression lines, fillers restore volume, and lasers may target pigmentation or texture. However, these treatments are not automatically safe to perform together or on the same day. Radiofrequency heating may affect certain existing fillers, and sequencing depends on the product, treatment area, settings and medical history. At Joanna Vargas in New York City, medically guided consultations help determine whether XERF belongs in a personalized approach to skin rejuvenation.
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XERF and Thermage use monopolar radiofrequency energy to heat tissue and support collagen remodeling, while Ultherapy uses microfocused ultrasound with visualization to target selected tissue depths. XERF uses dual-frequency RF technology (6.78 MHz and 2 MHz), while Thermage FLX uses a single RF frequency of approximately 6.78 MHz. Ultherapy can target specific depths, including 1.5, 3.0 and 4.5 mm, depending on the treatment area and protocol. All three are non-surgical options for selected skin-laxity concerns, but they differ in energy delivery, comfort, clinical evidence and treatment planning. No device is universally best; the right choice depends on your anatomy, skin laxity, goals and medical evaluation.
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The dermal-epidermal junction (DEJ) is the structural foundation where the epidermis meets the dermis, and its deterioration drives visible aging. Clinical biopsy data from a 63-year-old male patient treated with E-50 Skin Booster after microneedling showed a 17% increase in rete ridge density, 52% increase in epidermal thickness, and 61% increase in basal keratinocyte density, demonstrating that targeted exosome delivery can restore the DEJ architecture that gives skin its density and firmness.
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